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Principal Scientist, Medicinal Chemistry

CHARM Therapeutics is a biotech focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning.  Our platform enables the rapid generation of highly differentiated clinical candidates, our ambition is to revolutionise drug discovery. 

CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK.  We are seeking an experienced Medicinal Chemist with a passion for scientific innovation.  The successful candidate will join a multidisciplinary, highly collaborative discovery team to drive our oncology-focussed drug discovery pipeline and invent novel medicines.  Utilising innovative medicinal chemistry problem-solving skills and leveraging CHARM’s 3D-Deep Learning Design platform, he/she will design innovative new molecules as well as being responsible for defining project strategy and driving execution.  In this role, the incumbent will contribute to the overall scientific deliverables of the research site by reviewing program and chemistry strategy.   He/she will help to identify and validate biological targets as we build our internal pipeline.  Furthermore, he/she will be responsible for collaborative engagement with the external scientific community.  To accomplish the above, the successful candidate will have excellent interpersonal, cross-functional collaboration and communication skills, in addition to rigorous scientific thinking.

Role Responsibilities:

  • Accountable for the delivery of high-quality chemical tools to enable target validation and generation of candidate-quality molecules for clinical assessment 
  • Define project related MedChem strategies and, in conjunction with other CHARM leaders, define and execute on overall strategy for Drug Discovery projects from Target ID to Candidate nomination 
  • Promote and maintain the highest levels of excellence in medicinal chemistry, with a personal commitment to extend and develop knowledge and expertise
  • Provide day to day technical guidance to a small team of medicinal chemists
  • Ensure timely decision-making and delivery of key objectives. Promote high levels of productivity and urgency, leading by personal example 
  • Foster collaboration with academic and biotech communities, ensuring the CHARM Chemistry team operates at the highest levels of scientific excellence 
  • Contribute to the critical evaluation and selection of new targets
  • Publish science in high quality journals
  • Give presentations on CHARMTx projects both at internal science meetings and externally at conferences
  • Maintain the highest levels of Health and Safety across the CHARM Medicinal Chemistry group

Educational Background: 

A PhD in Chemistry or related discipline is required 

Skills and Experience required: 

  • A minimum of 8 years of relevant industry experience in drug discovery  
  • Deep understanding of the field of medicinal chemistry and drug design principles 
  • Experience in validating targets and initiating drug discovery programs 
  • A track-record of supporting drug discovery projects into development; ideally including direct accountability for project leadership 
  • Experience of working across multiple target-types and gene families 
  • A strong understanding of the related scientific disciplines that are pertinent to drug discovery and early development (e.g., therapeutic area biology, chemical biology, ADME, formulation, structural biology, drug safety/toxicology, IP)  
  • Experience of working with CRO partners 
  • Effective communication skills, both verbal and written 
  • Collaborative, with the ability to work well as part of a team