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Associate Principal Scientist, Medicinal Chemistry

CHARM Therapeutics is a biotech focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning.  Our platform enables the rapid generation of highly differentiated clinical candidates, our ambition is to revolutionise drug discovery. 
 
CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK.  We are seeking an experienced Medicinal Chemist with a passion for scientific innovation.  The successful candidate will join a multidisciplinary, highly collaborative discovery team to drive our oncology-focussed drug discovery pipeline and invent novel medicines.  Utilising innovative medicinal chemistry problem-solving skills and leveraging CHARM’s 3D-Deep Learning Design platform, he/she will design new molecules to drive our oncology pipeline.  In this role, the incumbent will contribute to the overall scientific deliverables of the research site by helping to define program and chemistry strategy, and co-leading internal programs.   He/she will help to identify and validate biological targets as we build our internal pipeline.  Furthermore, he/she will engage with the external scientific community to further our scientific activities and build CHARM’s external reputation.  To accomplish the above, the successful candidate will have excellent interpersonal, cross-functional collaboration and communication skills, in addition to rigorous scientific thinking.
 

Responsibilities

  • Accountable for the delivery of high-quality chemical tools to enable target validation and generation of candidate-quality molecules for clinical assessment. 
  • Contribute to project-related MedChem strategies and execute on the overall strategy for Drug Discovery projects from Target ID to Candidate nomination. 
  • Promote and maintain the highest levels of excellence in medicinal chemistry, with a personal commitment to extend and develop knowledge and expertise.
  • Ensure timely decision-making and delivery of key objectives.  Promote high levels of productivity and urgency, leading by personal example. 
  • Foster collaboration with academic and biotech communities, enabling the CHARM Chemistry team to operate at the highest levels of scientific excellence. 
  • Contribute to the critical evaluation and selection of new targets.
  • Publish science in high quality journals.
  • Give presentations on CHARMTx projects both at internal science meetings and externally at conferences.
  • Maintain the highest levels of Health and Safety across the CHARM Medicinal Chemistry group.

Educational requirements

A PhD in Chemistry or related discipline is required 

Skills and Experience requirements

  • A minimum of 5 years of relevant industry experience in drug discovery.  
  • Deep understanding of the field of medicinal chemistry and drug design principles. 
  • A track-record of supporting drug discovery projects; ideally including direct accountability for project leadership. 
  • Experience of working across multiple target-types and gene families. 
  • A broad understanding of the related scientific disciplines that are pertinent to drug discovery and early development (e.g., therapeutic area biology, chemical biology, ADME, formulation, structural biology, drug safety/toxicology, IP).  
  • Experience of working with CRO partners.
  • Experience in validating targets and initiating drug discovery programs is a plus .
  • Effective communication skills, both verbal and written.
  • Collaborative, with the ability to work well as part of a team.